The XRD patterns of GZ, GZ-PXM 188 and GZ-PXM 407 physical mixture, and GZ-PXM 188 or GZ-PXM 407 SDs were are shown in Figure 3. In the X-ray differactogram of pure GZ, a sharp peak is presented at a diffraction angle (26), are presented and it confirms that the drug is in the crystalline form. Typical diffraction peaks of GZ in physical mixture indicating indicate the presence of free crystalline drugs, which were revealed by few broad peaks of low intensity which that emerged on the background of PXM as an amorphous carrier. The reduction in intensity and number of typical diffraction peaks of GZ in SD X-ray diffractogram suggests the reduction in the crystalline nature of drug.
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